Cholula, is a city and district located in the metropolitan area of Puebla, Mexico. Cholula is best known for its Great Pyramid, with the Iglesia …Cholula, is a city and district located in the metropolitan area of Puebla, Mexico. Cholula is best known for its Great Pyramid, with the Iglesia de Nuestra Señora de los Remedios sanctuary on top, as well as its numerous churches.