Roussillon is a commune in the Vaucluse department of the Provence-Alpes-Côte d'Azur region in Southeastern France. It is a member of L…Roussillon is a commune in the Vaucluse department of the Provence-Alpes-Côte d'Azur region in Southeastern France. It is a member of Les Plus Beaux Villages de France Association. Roussillon lies within the borders of the Natural Regional Park of Luberon. In the French natural regional parks system, new economic activities may be developed only if they are sustainable.