ROME (AP) — Iran and the United States prepared for a fifth round of negotiations over Tehran’s rapidly advancing nuclear program Friday in Rome, with enrichment emerging as the key issue.

Iran and the United States began a fifth round of high-stakes nuclear talks in Rome on Friday amid growing skepticism in Tehran about the chances of a deal as Washington hardens its position.

Iranian and US negotiators met in Rome on Friday for a fifth round of nuclear talks, after a public disagreement over Tehran's uranium enrichment. The talks, which began in April, are the highest-level contact between the foes since the United States quit a landmark 2015 nuclear accord during President Donald Trump's first term.