The San Francisco 49ers can't catch a break in their offensive backfield. It started in training camp when running back ...

The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because ...

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained ...

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

The San Francisco 49ers running back is questionable with a sprained foot, but per ESPN’s Adam Schefter: he “plans to play” ...

ESPN insider Adam Schefter reported that San Francisco 49ers rookie running back Isaac Guerendo is unlikely to play against ...

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances ...

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of ...

Isaac Guerendo's status for Thursday's game is "up in the air" after suffering a foot sprain in a win vs. the Bears.

San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images The San Francisco 49ers are already down Jordan Mason and Christian McCaffrey in their backfield (both are on injured ...

Reporting emerged earlier on Thursday noting that 49ers running back Isaac Guerendo is unlikely to play in Sunday's game ...

PM ET game airing live on Amazon Prime Video, bookmakers have posted player props for Isaac Guerendo. NFC West rivals play in ...