No. 18 Michigan inflicted a pair of significant blows in the first half against No. 11 USC on Saturday, taking a 14-3 lead into the break behind stingy defense and explosiveness in its run game. Kalel Mullings busted a 53-yard touchdown run on the Wolverines' third possession to open the scoring after the teams traded early punts.

The Wolverines grinded out a win over the Trojans, plus the rest of the weekend’s most notable winners and losers.

There are highs and lows every week in college football. The winners and losers for Week 4 start with Southern California's loss to Michigan.