The Rams are too injured and while the 49ers are just injured. Their lines are both healthy which will be critical for running the ball and getting to Matthew Staffo

The Rams will also be without key players as star wideouts Cooper Kupp and Puka Nacua are both out; Nacua is on injured reserve with a knee injury stemming from Week 1 while Kupp was ruled out with an ankle injury suffered last week. Los Angeles already has five offensive linemen on IR.

The Rams are big underdogs against the 49ers today. Can they pull off the upset? Here’s our final score prediction.