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PURPOSE: To evaluate the safety and efficacy of alteplase (TPA) for restoring function to occluded central venous catheters (CVCs). PATIENTS AND METHODS: The study design was a phase III, open-label, ...

The American Heart Association/American Stroke Association has issued a new scientific statement on the rationale for the inclusion and exclusion criteria for intravenous alteplase (tissue plasminogen ...

PRAGUE, Czech Republic — A 0.4-mg/kg bolus dose of tenecteplase (TNKase, Genentech) was associated with functional outcomes and safety similar to those seen with the standard of care, alteplase ...

A noninferiority trial comparing two doses of thrombolytic therapy with the tissue plasminogen activator (tPA) alteplase has failed to demonstrate that low-dose therapy is as effective as ...

Among patients presenting directly to a thrombectomy-equipped center with a large-vessel ischemic stroke, going directly to the endovascular suite and forgoing initial IV thrombolytic therapy provides ...

CINCINNATI--While the gold standard for stroke care is the use of IV tissue plasminogen activator (tPA, or product name Alteplase) to dissolve clots and mechanical thrombectomy to remove clots in ...

In a meta-analysis presented at the European Stroke Organization Conference, alteplase was more effective than placebo for treatment of acute ischemic stroke between 4.5 and 9 hours after onset.

LOS ANGELES, Feb. 18 (UPI) --A clot-busting drug used for heart attacks and non-bleeding strokes can be used to reduce post-stroke disability and mortality in patients with a type of bleeding stroke, ...

Outcomes after stroke thrombectomy were not better with tissue plasminogen activator (tPA) withheld, according to the MR CLEAN-NO IV trial. Of more than 500 acute stroke patients with large vessel ...

Review the side-effects of Alteplase as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the ...