Kappa-opioid receptor (KOR) agonists represent a promising class of compounds that modulate pain, mood and various neurobehavioural processes. Unlike traditional opioids that primarily target the ...

Irritable bowel syndrome (IBS) is a common digestive disorder that affects the intestine, causing symptoms such as abdominal ...

New research suggests that δ-receptor agonists regulate intestinal motility and relieve abdominal pain in a mouse model of ...

The current gold standard therapy for opioid addiction is a "replacement therapy" where a less efficacious opioid is given to the patient. However, patients often have difficulty abstaining from ...

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose. In a study ...