The Cdc25 phosphatases (Cdc25A, B and C) regulate eukaryotic cell-cycle progression through the dephosphorylation and activation of their substrates, the CDK–cyclin complexes (Boutros et al., 2006).
DNA double-stranded breaks (DSBs) elicit a checkpoint response that causes a delay in cell cycle progression. Early in the checkpoint response, histone H2AX is phosphorylated in the chromatin region ...
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