Nature

Predicting expression patterns from regulatory sequence in Drosophila segmentation

Precise spatio-temporal control of gene expression lies at the heart of metazoan development. The necessary instructions are encoded in cis-regulatory elements, or modules, which typically contain ...
The New England Journal of Medicine

Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A

The goal of gene therapy for patients with hemophilia A is to safely impart long-term stable factor VIII expression that predictably ameliorates bleeding with the use of the lowest possible vector ...
Nature

Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media

Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of ...
FierceBiotech

Expression Therapeutics LLC Selects ABL, Inc. to Support Cell Line Development for Hemophilia A Factor VIII Infusion Therapy

TUCKER, Ga. & ROCKVILLE, Md.--(BUSINESS WIRE)--Expression Therapeutics LLC, a biotechnology company developing high expression factor VIII technologies, together with ABL, Inc., a biomedical contract ...
The New England Journal of Medicine

Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant

The prevention of bleeding with adequately sustained levels of clotting factor, after a single therapeutic intervention and without the need for further medical intervention, represents an important ...