New work from UC Davis and the University of Utah shows how the 3D structure of DNA inside a germ cell commits it to develop into a sperm cell. The discovery could improve understanding of fertility ...

Before cells can divide by mitosis, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material. Scientists have until now ...

Before cells can divide, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material. Until now, scientists had believed that ...

The origin of many diseases begins at the cellular level and involves multiple molecular interactions. However, previous methods have struggled to accurately observe changes in individual cells.

DNA might be too small to see with the unaided eye, but it packs our cells in shocking quantities: More than six and a half feet of DNA lies within every cellular nucleus. It squeezes into such a ...

Gene regulation and chromatin dynamics constitute central themes in modern molecular biology, governing how the genetic blueprint is accessed and utilised during development, differentiation and ...

For decades, scientists viewed the genome of a newly fertilised egg as a structural 'blank slate' – a disordered tangle of DNA waiting for the embryo to 'wake up' and start reading its own genetic ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing ...

The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

Influenza A virus (IAV) possesses a segmented, negative-sense RNA genome comprising eight distinct viral RNA (vRNA) segments. These segments form ribonucleoprotein (RNP) complexes that are selectively ...

Researchers showed how what appears to be a tangle of DNA is actually organized into a structure that coordinates thousands of genes to form a sperm cell. The work, published as two papers in Nature ...