After years of neglect, glial cells are finally registering on drug developers' radar. This reflects increasing knowledge not only about their immunological functions, particularly those related ...

How does the brain store—and access—our memories? While our understanding of the brain has (thankfully) developed greatly from the days of removing cerebral tissue to see what would happen, a precise ...

However, glial cells in the brain continue to divide throughout ... making evidence of apoptosis difficult to detect. Tissue function depends on more than cell type and proper rates of death ...

a class of glial cells with many known neuroprotective functions, and perineuronal nets (PNNs), structures that form a ...

The Deneen Lab seeks to unlock the enigmatic biology surrounding glial cell development and function in the brain. Beginning with developmental gliogenesis, we identified the key transcriptional ...

When several genes important to mitochondrial function were suppressed in the brains of young flies, senescent glial appeared. Chopra’s lab performed large-scale lipidomics on cells isolated from ...

The increasing implication of glial cells in neurodegenerative diseases makes them an appealing addition to iPSC-based model systems for investigating disease mechanisms.

We are interested in the molecular mechanisms by which cells acquire glial fate and function during development and maintain their functionality throughout life. We leverage this knowledge to define ...

The nervous tissue in the brain, for example, is composed of neurons, which transmit the signals, and the supporting glial ...