The beating of a heart, the ability to learn and remember, and the movement of a sperm cell's tail all have at least one thing in common: They depend on the function of ion channels, the membrane ...

The field of optogenetics has revolutionised our ability to manipulate neuronal circuits by harnessing light-sensitive ion channels to control cellular activity with unprecedented precision. At its ...

Mutated variants of a particular ion channel cause difficult-to-treat epilepsy. A study published in the journal Nature now shows that a commonly used anesthetic drug, propofol, can restore the ...

The Nalcn ion channel is a unique, voltage‐independent sodium leak channel that plays a critical role in controlling neuronal excitability by contributing to the basal resting membrane potential. Its ...

Johns Hopkins Medicine researchers discover that blocking the ion channel called TRPC6 in genetically modified mice with severe or moderate Duchenne muscular dystrophy (DMD) substantially improves ...

Research at UC San Francisco has shown for the first time how the commonly prescribed seizure and pain medication, gabapentin, acts inside of cells, opening the door to new, more effective treatments ...

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers have ...

A faulty ion channel function is a consistent biological feature of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), providing long-awaited validation for hundreds of thousands of ...

Researchers decipher the function of an ion channel involved in cellular degradation processes and create new possibilities for Parkinson’s therapies. Washbowls, bathtubs, and sinks are all fitted ...

A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a study led by researchers at Weill ...

Researchers report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne ...