Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Fats are an important part of the human diet as a major source of energy. Around 90% of the fat stores are on top of muscle, so just under the skin. However, excessive dietary fat intake leads to fat ...

The liver plays a vital role in maintaining overall health. It filters toxins, supports digestion through bile production, stores nutrients, and regulates blood sugar and fat metabolism. Because of ...

The liver, located in the upper right side of the abdomen, is the body’s largest organ and one of the most important. The liver performs hundreds of vital functions, including converting nutrients ...

Over time, this damages liver cells, triggers inflammation and contributes to fibrosis, which is the build-up of scar tissue. If scarring becomes extensive, it can progress to cirrhosis, a stage where ...

Dr. Chander Negi prepares samples using the PhysioMimix LC12 liver-on-a-chip system as Dr. Ivan Rusyn looks on in their Texas A&M research laboratory. Creating a drug that might help treat or cure a ...