T cells are central to adaptive immunity, orchestrating targeted responses against infections and malignancies while forming a durable immunological memory. Memory T cells, particularly CD8+ subsets, ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...

Memory T cell therapy improves infection clearance after transplant, with 60% remission and strong safety outcomes in early ...

During vaccination, the immune system is purposefully exposed to weakened, inactivated, or a component of pathogens so that the body can recognize their molecular structures in the future and mount a ...

A University of Pennsylvania study has demonstrated that a dual-action lipid nanoparticle can reverse T-cell exhaustion and ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...

Commercialization ready compound supports a new method of generating highly functional human CAR-T cells for treating infectious diseases and cancer In experimental models, human CAR-T cells ...

T-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma cells in response to a second infection BIRMINGHAM, Ala. – ...