The Notch signaling system links cellular fate to that of its neighbors, driving proliferation, apoptosis, and cell differentiation in metazoans, whereas dysfunction leads to debilitating ...

Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for ...

Researchers at the Karolinska Institute have used DNA origami to demonstrate how an important cell receptor can be activated in a previously unknown way. The new study provides insight into how the ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

(Nanowerk News) Researchers at Karolinska Institutet have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously ...

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in ...

Rajwinder Lehal, Jelena Zaric, Michele Vigolo, Charlotte Urech, Viktoras Frismantas, Nadine Zangger, Linlin Cao, Adeline Berger, Irene Chicote, Sylvain Loubéry, Sung ...

Chimeric antigen receptor (CAR) T cell therapy is a promising immunotherapy against cancer. The idea is to fortify a person’s immune system to fight its own battle by boosting T cells with the ability ...