Genetic studies of this type are relying increasingly on extremely polymorphic microsatellite loci (section 8.3) to produce anchored linkage maps (chapter 9), and large insert cloning vectors — such ...

Transcript abundances of genes are directly modified by polymorphism in regulatory elements ... as one means of characterizing the function of loci underlying complex disease traits.

This is a unique challenge when obtaining genetic data from highly polymorphic loci, a characteristic typical of many genes central to the immune response. For genetic analysis, we developed ...

The recent union of molecular genetic methods and ecology is a great ... is unknown is to sequence fragments derived from polymorphic loci. One marker method known as sequence characterized ...

This finding stands in stark contrast to the high level of non-polymorphism observed at the majority of loci examined within the classical inbred lines. The significance of the interspecific cross for ...

The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can ...

Sequence variations in drug disposition genes can alter the pharmacokinetics of a drug, while sequence variations in drug target genes can change the pharmacodynamics of the drug. The two most ...

Single Nucleotide Polymorphism (SNP)-based heritability ... The study replicated 39% of previously reported loci and provided insights into genes that specifically affect individual brain volumes.

Where genes are associated with CD and UC, the p-values are given from the index gene discovery study; this is CD for all the genes presented here. * Colonic CD only. ‡ Early-onset disease ...

These latter outcomes are driven by the exchange of a suite of polymorphic toxins that vary widely between ... Rapid diversification of wild social groups driven by toxin-immunity loci on mobile ...

Genomic Informational Field Theory (GIFT) enhances genetic association detection, outperforming GWAS in mapping complex ...

Their high level of polymorphism makes them suitable for distinguishing between individuals based on genetic variations ...