The mechanism of action of NNRTIs is illustrated in Figure 1. Reverse transcriptase catalyzes RNA-dependent and DNA-dependent polymerase activities, which are essential for viral DNA synthesis when ...

Researchers show that polymerase theta can efficiently convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells. Editor's Note: Thomas Jefferson University issued the ...

The global reverse transcriptase enzymes industry has witnessed remarkable growth and is anticipated to further expand, reaching a valuation of US$ 335.0 Million in 2022 and projected to escalate to ...

One of the hallmarks of many DNA polymerases is that they proofread as they copy DNA, ensuring high-fidelity duplicates of an organism’s genome. This error-checking ability is missing from enzymes ...

Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older. The disease has proven difficult to develop new treatments for, and available ...

If you're getting treated for an HIV infection, your doctor may suggest a type of drug called an NRTI. It's short for "nucleoside/nucleotide reverse transcriptase ...

† Drugs combined with NRTIs or NRTIs/NNRTIs are not listed. NNRTIs: Non-nucleoside reverse-transcriptase inhibitors; NRTIs: Nucleos(t)ide analog reverse-transcriptase inhibitors. Drug-resistance amino ...

Prime editing uses specialized machinery consisting of a prime editing guide RNA (pegRNA) and a Cas9 enzyme fused to a reverse transcriptase. The version of Cas9 used in prime editing has one of its ...

New Jersey : According to a study co-authored by a Rutgers researcher, the crystal structure of a human endogenous reverse transcriptase is comparable to HIV reverse transcriptase, a well-known ...

New research shows a transcriptase that helps time cell death varies in expression, and is unusually localized, in cancer cells. The transcriptase, Telomerase Reverse Transcriptase (TERT), is ...