The San Francisco 49ers resume their quest for the No. 1 seed in the NFC West - yes, seriously - by facing the Tennessee Titans, who are tied for the worst record in the NFL.

The biggest game of the year is almost here, with the Kansas City Chiefs and San Francisco 49ers soon going to battle in a rematch of Super Bowl LIV. This year, Super Bowl LVIII in Las Vegas will host two of the league's best teams from this season.

It wasn’t a pretty first half, but the San Francisco 49ers bounced back to blow out the Cleveland Browns in Week 13.

At 7-4 the San Francisco 49ers remain in the division race despite playing in the highly competitive NFC West. The team appeared poised for a postseason push with injury returns providing an infusion of talent for the stretch run. However, San Francisco ...

Now the San Francisco 49ers look like a team that might be peaking at the right time. Purdy threw three touchdown passes, Christian McCaffrey had two rushing touchdowns and a receiving score, and the 49ers beat the sloppy Arizona Cardinals 41-22 on Sunday.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

So, the 49ers don’t have a good rushing offense and are facing an elite run defense. And the Colts have a great rushing attack and are facing a below-average run defense. Usually, the team that struggles more in the trenches loses.

Which team will win the NFL Week 16 game on Monday Night Football? Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 6:15 p.m. MST on ESPN (stream with FUBO).