The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become ...

Extended Lymph Node Dissection for Gastric Cancer: Who May Benefit? Final Results of the Randomized Dutch Gastric Cancer Group Trial Circulating cytokines, hormones, and growth factors control all ...

Signal transduction is the fundamental process by which cells convert external cues into tailored intracellular responses. Through a cascade of molecular events—beginning at the cell membrane with the ...

Comparison of the simulation treatment planning of FLT and FDG PET/CT in contouring the biologic tumor volume in patients with thoracic esophageal carcinoma. A phase I/II trial of continuous hepatic ...

Signal transduction is a key mechanism that brings about several physiological responses in a cell. Aberrant signaling can result due to gene mutations or regulatory protein overexpression. It is ...

In recent years, immune checkpoint therapy headed by programmed death receptor 1 (PD-1) and programmed death receptor-ligand 1 (PD-L1) has been proven to be safe and effective. However, clinical ...

Recludix Pharma Inc. has disclosed signal transducer and activator of transcription 3 (STAT3) and/or STAT6 inhibitors reported to be useful for the treatment of cancer and inflammatory disorders.

This is a preview. Log in through your library . Abstract The primary task of a spermatozoon is to deliver its nuclear payload to the egg to form the next-generation zygote. With polyandry repeatedly ...

In a study of mice, researchers worked out a neural pathway that could help researchers alleviate nausea symptoms from chemotherapy drugs. By Veronique Greenwood Anyone who’s had a shady oyster or a ...

Edited by: James Kling P.A. Hoodless, T. Haerry, S. Abdollah, M. Stapleton, M.B. O'Connor, L. Attisano, J.L. Wrana, "MADR1, a MAD-related protein that functions in ...

STRESSED OUT: Jöel Raingeaud, left, and Roger Davis found that the p38 MAP kinase is activated by inflammatory cytokines and environmental stress. J. Raingeaud, S ...