The San Francisco 49ers (8-4) will play the Cleveland Browns (3-8) at Huntington Bank Field on Sunday, Nov. 30 at 1 p.m. ET, and our computer prediction is a lopsided victory by the 49ers, 27-15. San Francisco has seven wins in 12 games against the spread this year.

There are plenty of matchups to focus on in Sunday's battle between the 49ers and Browns, but these are the most important.

See insights on prop bet options below in this article, including first to score and player prop bet insights. NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 1:41 p.m. ET. For a full list of sports betting odds,

Mary Kay Cabot, Ashley Bastock and Dan Labbe come up with storylines and make picks for Sunday's Browns game against the 49ers.

The San Francisco 49ers take on the Cleveland Browns at Huntington Bank Field in Cleveland on Sunday, Nov. 30 at 10 a.m. PT. The 49ers are coming off a Monday Night Football win at home over the Carolina Panthers,

Deion Sanders was Kyle Shanahan’s favorite player when his father, Mike Shanahan, was the San Francisco 49ers’ offensive coordinator during their 1994 Super Bowl season. On Sunday, Shanahan will table his adoration of the Pro Football Hall of Famer for a couple of hours as he looks to stop his son,

Preview the San Francisco 49ers' NFL Week 13 matchup with the Browns, including live stream, TV channel, odds, and game information.