BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart ...

BACKGROUND: Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality rates, including heart failure, multisystem end-organ ...

Evidence of myocardial injury does not necessitate a diagnosis of myocarditis. When a cardiac troponin level is over the 99th percentile of the upper reference limit, 6 there exists a spectrum of ...

Identification of children with latent rheumatic heart disease (RHD) by echocardiography, before onset of symptoms, provides an opportunity to initiate secondary prophylaxis and prevent disease ...

BACKGROUND: Evaluation of whether dyspnea has a cardiac cause is essential. Guidelines from 2016 were reported to result in a ...

Glycoursodeoxycholic acid (GUDCA) has been acknowledged for its ability to regulate lipid homeostasis and provide benefits for various metabolic disorders. However, the impact of GUDCA on arterial ...

A cardiac catheterization takes ≈45 minutes to complete. After a coronary angiogram, depending on the severity and pattern of any blockages detected in the coronary arteries, 3 common treatment paths ...

In the United States, SCD is recognized as a leading cause of death. However, its relative public health burden, especially in younger Americans, remains less clear. 4 Previous investigations ...

Valvular heart disease (VHD) is one of the most common diseases in the United States, with an estimated prevalence of 2.5% among adults. 1, 2, 3 Among VHD, aortic and mitral valvular diseases are the ...

Childhood obesity has been referred to as a global pandemic. In both developed and developing countries, the prevalence of childhood obesity has significantly increased over the past 40 years. 1 ...

Gene Ontology analysis from differentially expressed genes revealed expected changes in cell cycle, metabolism, and contractility. In addition, mRNA splicing was among the top enriched differentially ...

Despite decades of technique refinement of transarterial embolization and the establishment of specialty referral centers, fetuses diagnosed with vein of Galen malformation continue to have high ...