Venezuela also seeks their first World Cup appearance in history. Currently sitting seventh in the standings, they would be in an intercontinental playoff for a chance at a World Cup berth, and now with a four-point lead on Bolivia, they will set their eyes on catching Colombia for direct qualification instead of the playoff.

Carlo Ancelotti, the legendary Italian tactician and former Real Madrid boss, is set to lead the Selecao for the first time when Brazil takes on Ecuador.

Ecuador takes on Brazil on Thursday at the Estadio Monumental Banco Pichincha in Guayaquil, with kickoff set for 6 p.m. ECT local time in Ecuador. That makes it an 8 p.m. BRT in Brazil, a 7 p.m. ET or 4 p.m. PT kickoff in the US and Canada, a 12 midnight BST start in the UK and a 1 a.m. AEST kickoff in Australia on Friday.