In this valuable study, through carefully executed and rigorously controlled experiments, the authors challenged a previously reported role of the Death Receptor 6 (DR6/Tnfrsf21) in Wallerian ...

This important study uses innovative microfluidics-based single-cell imaging to monitor replicative lifespan, protein localization, and intracellular iron levels in aging yeast cells. The evidence for ...

This interesting study adapts machine learning tools to analyze movements of a chromatin locus in living cells in response to serum starvation. The machine learning approach developed is useful, the ...

The effects of transcranial direct current stimulation on cortical dynamics depend on the state of consciousness and the stimulation polarity.

The authors describe an interesting approach to studying the dynamics and function of membrane proteins in different lipid environments. The important findings have theoretical and practical ...

CA1 pyramidal neurons exhibit synchronous spiking during movement and pauses in novel environments, reflecting a neural signature of spatial learning.

A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of ...

KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic ...

Machine learning with whole-cell patch-clamp and local field potential recordings reveals that synaptic responses from five mossy cells, despite their limited population, can significantly reconstruct ...

Introducing premature visual experience by opening the closed eyelids early in ferrets caused many cells in the primary visual cortex to mature improperly.

Imperial College London and the University of Sheffield have signed up to eLife’s uncapped scheme in support of a more open, equitable and sustainable science publishing system.

Individual retinal ganglion cells are singularly activated in the living primate retina via an adaptive optics scanning light ophthalmoscope.