Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Animals entrain their circadian rhythms to ...

Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer ...

miPEP31, encoded by the primary transcript of miR‐31, is a cell‐penetrating peptide which promotes Treg differentiation. Synthesized miPEP31 enhances the induction of peripheral Tregs and suppresses ...

Intriguingly, single-cell transcriptome profiling of fetal gonads from both humans and mice shows that MCM8 is also highly expressed in PGCs undergoing rapid mitosis (Li et al, 2017; Niu and Spradling ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

We recently discovered that the binding of mitochondrial precursor proteins to the ER surface is not simply the result of an unavoidable mislocalization, but rather that the ER-to-mitochondria ...

Motile cells can use and switch between different modes of migration. Here, we use traction force microscopy and fluorescent labeling of actin and myosin to quantify and correlate traction force ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

In this study, we generated new in-vivo treatment models of Brca1- and Bard1-mutant breast cancer that recapitulate the striking response to PARPi, acquired resistance, and recurrence that is observed ...