At the Santiago Bernabeu, Real, who sit third in La Liga, edged Atletico, who are second, in a game illuminated by three dazzling goals.
SportsLine's proven computer model has revealed its UEFA Champions League score predictions, top picks for Tuesday's schedule
Real Madrid secured a crucial 2-1 win over local rivals Atletico in the first leg of the Champions League last 16, while Arsenal thumped PSV 7-1. Aston Villa also secured a win while Lille registered a draw against Borussia Dortmund.
The round of 16 is officially underway in the UEFA Champions League with several teams halfway to a spot in the quarterfinals after first-leg action. Arsenal, Aston Villa and Real Madrid all carry advantages heading into next week's second leg,
Play-off hero Anwar El Ghazi is relishing an emotional return to Villa - just months after he feared his career was over.
The UEFA Champions League returns Mar. 4 with the first legs of round of 16 fixtures. Real Madrid takes on Atlético Madrid in Tuesday's highlight fixture while Arsenal, Aston Villa, Borussia Dortmund and more are in action. Sports Illustrated gives our predictions for the full slate of first leg Champions League fixtures on Tuesday.