Oncologists caution that at-home genetic tests taken up by millions of Americans looking to gauge their cancer risk are not ...

Medically reviewed by Adam M. Brufsky, MD, PhD The exact cause or causes of triple-negative breast cancer are unknown, but ...

Ask yourself how the genetic test results may affect your life. If the results come back positive, will you take steps to ...

The panels assess genes with strong disease links and clinical management guidelines, but the firm offers limited-evidence genes as an add-on option.

These proteins are related to the genetic material of cancer cells. For example, with estrogen receptor-positive breast cancer ... Low prevalence of HER2 positivity amongst BRCA1 and BRCA2 mutation ...

We identified the breast cancer gene BRCA2, which enabled families with a history of breast cancer to be assessed for future risk, and laid the groundwork for developing novel forms of therapy for ...

"We are hopeful that further research will reveal similar splicing mechanisms in BRCA2 and other genes that relate to HRD." HRD (homologous recombination deficiency) is found in approximately 50% ...

In 1994, by studying families with unusually high numbers of breast cancers, we pinpointed that mutations in a new gene, which we called, BRCA2, can cause breast and ovarian cancer. Women with a BRCA2 ...

or positive for a variant of uncertain significance (VUS) were reported for each patient group. The actual variants and associated genes were reported as well. Clinical and pathologic features of the ...

Researchers worked with two labs to identify 16 consensus lower-risk pathogenic variants and are pushing for greater ...