GEN9h
Combining Base and Prime Editing to Decipher Which Gene Variants Lead to Cancer
Researchers at ETH Zurich combined two CRISPR-Cas methods to decipher how mutations in a cell’s genome affect its function.
Baylor College of Medicine6d
Grants awarded to researchers at the Center for Cell and Gene Therapy
ScaleReady, in collaboration with Wilson Wolf Manufacturing and Bio-Techne Corporation and CellReady, has awarded G-Rex ...
Genetic repair via CRISPR can inadvertently introduce other defects, researchers show
The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can ...
EurekAlert!1d
Using CRISPR to decipher whether gene variants lead to cancer
Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of ...
Science Daily6d
Use of 'genetic scissors' carries risks
The CRISPR tool is capable of repairing the genetic defect responsible for the immune disease chronic granulomatous disease. However, researchers have now shown that there is a risk of inadvertently ...
eLife6d
Acute Activation of Genes Through Transcriptional Condensates Impact Non-target Genes in a Chromatin Domain
Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...
Nature3d
Targeted gene repair articles from across Nature Portfolio
ReChb is a Cas12a nuclease with expanded target access and substrate recognition. CRISPR–Cas9 technology is a powerful tool for immune cell engineering. Ex vivo editing has progressed to ...