Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

DNA damage response, or DDR for short, is the technical term for this. Specific signaling pathways usually initiate the immediate recognition and repair of DNA damage, thus ensuring the survival ...

DNA damage response, or DDR for short, is the technical term for this. Specific signaling pathways usually initiate the ...

A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 ...

Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to ...

The mammalian DNA repair process has evolved over time into a number of complex pathways to cope with all of the alterations that can occur to the structure of DNA. The past 30 years have seen a ...

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in ...

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes ...

The nicotinamide adenine dinucleotide (NAD+) peptide, an essential coenzyme believed to be involved in fundamental cellular ...

The grant will fund exploration of DNA replication and target therapeutic pathways for cancer treatment ... Surtees has also been exploring disabling cells’ mismatch repair system, or MMR, which acts ...