E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

E6 associates with p53 and targets it for rapid degradation mediated by the ubiquitin ligase E6-associated protein ... that is part of the β-catenin degradation complex, lead to stabilization ...

Early work determined structures of the SUMO E1 in complex with SUMO and ATP and elements ... a feature shared with many other ubiquitin and ubiqutin-like E3 ligases. Subsequent studies revealed a ...

We have selected the protein group of RING type ubiquitin E3 ligases to assign them in plant developmental stages and organs by gene expression profiles, by high throughput phenotyping of ...

They found that cells missing FBXO31, a substrate adaptor for the SCF ubiquitin ligase complex, were unable to clear CTAPs. SCF ubiquitinates target proteins, delivering them to the proteasome ...