The ubiquitin proteasome system (UPS), a 76-amino acid complex, is a key regulator of protein catabolism ... CRL4 (Cullin-RING ubiquitin ligase) is an E3 ubiquitin ligase, composed of three subunits ...

USP44 deubiquitylates CDC20, a co-activator of the E3 ubiquitin ligase anaphase promoting complex or cyclosome (APC/C) that promotes the degradation of many key cell cycle regulators. USP44 ...

They found that cells missing FBXO31, a substrate adaptor for the SCF ubiquitin ligase complex, were unable to clear CTAPs. SCF ubiquitinates target proteins, delivering them to the proteasome ...

E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Mechanically, we demonstrated that E3 ligase TNF receptor–associated factor 6 (TRAF6) participated in the ubiquitination of TBK1 in cGAS-STING signaling pathway. We showed that pA151R interacted with ...

Motorola Moto E3 mobile was launched in July 2016. The phone comes with a 5.00-inch touchscreen display offering a resolution of 720x1280 pixels. Motorola Moto E3 is powered by a 1GHz quad-core ...