Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

The ubiquitin proteasome system (UPS), a 76-amino acid complex, is a key regulator of protein catabolism ... CRL4 (Cullin-RING ubiquitin ligase) is an E3 ubiquitin ligase, composed of three subunits ...

PROteolysis TArgeting Chimeras (PROTACs) are small molecules that induce target protein degradation via the ubiquitin-proteasome system. PROTACs recruit the target protein and E3 ligase; a critical ...

USP44 deubiquitylates CDC20, a co-activator of the E3 ubiquitin ligase anaphase promoting complex or cyclosome (APC/C) that promotes the degradation of many key cell cycle regulators. USP44 ...

The platform studies E3 ubiquitin ligases, enzymes that allow the selective ... has so far presented promising results in patients with complex B-cell malignancies. According to Seeking Alpha ...

second that the essential roles of TRAF6 in initiating innate immune signalling are independent of its E3 ligase activity; third that the HOIL-1 component of the Linear Ubiquitin Assembly Complex ...

Under normal growth conditions, N-myc downstream regulated gene 3 (NDRG3) undergoes hydroxylation by PHD2 and ubiquitinated for degradation by VHL, a targeted element of the E3 ubiquitin ligase ...

Importantly, AUCell analysis revealed that CHIP E3 ubiquitin ligase activity deficiency affected ubiquitin-mediated proteolysis, ultimately increasing the level of intracellular cAMP. The activation ...

They found that cells missing FBXO31, a substrate adaptor for the SCF ubiquitin ligase complex, were unable to clear CTAPs. SCF ubiquitinates target proteins, delivering them to the proteasome ...

Vivek Vishnudas discusses the unique advantages of E2-based TPD and its potential to revolutionize treatment for challenging diseases.