Image Caption: The human and mouse expression profile of FGF8. (A) Relative abundance of FGF8 in adult human tissues from the Genotype-Tissue Expression (GTEx V8) Project Consortium (TPM, transcripts ...
Living in a murky lake around Mexico City, surrounded by aggressive and cannibalistic neighbors, the axolotl lives at constant risk of losing a limb to a neighbor's nibble. Fortunately, lost limbs ...
FGF-8 is a member of the fibroblast growth factor family, originally identified as essential for the androgen-dependent growth of mouse mammary carcinoma cells. In mice, alternative splicing of the ...
Nager syndrome (NS) is an extremely rare disease that causes developmental problems and anomalies in facial bone structures and limbs. While the causative gene is known, its underlying mechanisms ...
The morphogen FGF8 establishes graded positional cues imparting regional cellular responses via modulation of early target genes. The roles of FGF signaling and its effector genes remain poorly ...
Jaws are a key characteristic that facilitated the radiation of the vertebrate clade by expanding dietary niches. Vertebrates exhibit diversity in jaw size and shape, indicating that jaw development ...
Asymmetries in craniofacial anomalies are commonly observed. In the facial skeleton, the left side is more commonly and/or severely affected than the right. Such asymmetries complicate treatment ...
In the interests of transparency, eLife publishes the most substantive revision requests and the accompanying author responses. [Editors' note: this paper was reviewed by Review Commons.] Reviewer #1 ...
The tuberal hypothalamic ventral premamillary nucleus (VPM) described in mammals links olfactory and metabolic cues with mating behavior and is involved in the onset of puberty. We offer here ...
Lung squamous cell carcinoma (LSCC) is the most common subtype of non-small cell lung cancer. Immunotherapy has become an effective treatment in recent years, while patients showed different responses ...
The mechanisms used by embryos to pattern tissues across their axes has fascinated developmental biologists since the founding of embryology. Here, using single-cell technology, we interrogate complex ...
The ability of cells to migrate collectively underlies many biological processes. The parapineal is a small group of cells that requires Fgf8 to migrate from the midline to the left side of the ...
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