They also identified specific types of neurons that are lost very early in disease: a specific type of inhibitory interneuron that helps dampen neural activity. The loss of these "SST neurons ...

Here the authors show that LINE-1 sequences can jump in mouse parvalbumin interneurons and also promote the transcription of key parvalbumin interneuron genes. Traditional systematic anti-seizure ...

Studies using acute slicing preparations to examine circuit effects have often been limited to the study of small microcircuits - especially feedforward and feedback interneuron circuits. It is widely ...

For example, many models identified increased excitation-inhibition (E-I) ratios and parvalbumin (PV) interneuron hypofunction as common circuit-level disruptions. These findings indicate that ...

Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, USA ...

Researchers have successfully demonstrated how astroglia – cells that support the functioning of the brain – can be ...

Nov. 8, 2024 — Changes in the gut microbiome before rheumatoid arthritis is developed could provide a window of opportunity for preventative treatments, new research ... Two Key Genes Identified ...

Nov. 7, 2024 — Hip implants with a delta ceramic or oxidized zirconium head and highly crosslinked polyethylene liner or cup had the lowest risk of revision during the 15 years after surgery, a ...

Brain-inspired Cognitive Intelligence Engine (BrainCog) is a brain-inspired spiking neural network based platform for Brain-inspired Artificial Intelligence and simulating brains at multiple scales.