Using unnatural base pairs, researchers have site-specifically biotinylated RNA, allowing them to immobilize an aptamer on a chip and detect its interaction with a target protein. Experiments with ...

Columbus, Ohio-based start-up Basking Biosciences has raised $55 million in an unspecific round that will be used to fund a phase 2 trial of BB-031, described as a first-in-class RNA aptamer ...

While antisense oligonucleotide and aptamer drugs have been on the market ... employed to fight against the COVID-19 pandemic that RNA-based therapeutics attracted the attention of the general ...

A research team has developed an RNA-based sensor platform that can regulate ... for sensors that require high selectivity. When an aptamer binds to its target, it triggers a structural change ...

A small molecule-type ligand blocked cleavage by binding with RNA aptamer sequences, thereby retaining intact mRNA and inducing transgenic expression. The Y-shaped structure of aptamers could ...

The AptaFluor SAH Methyltransferase Assay uses a highly sensitive RNA aptamer that is capable of directly detecting SAH. The sensitivity of the aptamer (measures SAH at concentrations below 10 nM ...

and Gregory et al have adapted the technology to create an RNA-based probe for use in MND. In time, the hope is that the aptamer could potentially be used not only to look for the biomarker in ...

Aptamers are short strands of nucleic acids (DNA or RNA) that bind specifically and ... for sensors that require high selectivity. When an aptamer binds to its target, it triggers a structural ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

In this Q&A, learn more about how Heonjoon Lee, fifth year biomedical engineering PhD student, found his niche in ...

The primary function of guanine is to store and transmit genetic information in DNA and RNA. In DNA, guanine is always paired with cytosine, and the sequence of these base pairs determines the genetic ...