Because of this flexibility, the 30 to 40 tRNAs present in a cell can "read" all 61 codons in mRNA. The opposite end of the folded structure, which is the 3' end of the tRNA, binds to its ...

Messenger RNA (mRNA) serves as a blueprint for proteins. When mRNA is no longer needed, it must be degraded. Director Elena ...

A recently discovered inhibitor shows new ways for the development of mRNA-based drugs.mRNA-based therapeutics and vaccines ...

Translation Begins After the Assembly of a Complex Structure The translation of mRNA begins with the formation of a complex on the mRNA (Figure 4). First, three initiation factor proteins (known ...

A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA. Achieving the opposite and stabilizing health-promoting mRNA is still ...

Messenger RNA–based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

"We hope that this paper can lead to new clinical applications for lipid nanoparticles by showing how simple alterations to their chemical structure can enable highly specific mRNA delivery to the ...

A new study has provided a detailed analysis of how mRNA vaccines circulate and break down in the human bloodstream. The research aimed to help improve the safety and effectiveness of these vaccines, ...

In an era where viral outbreaks can escalate into global pandemics with alarming speed, the ability to quickly develop new vaccines has become crucial.

The mRNA cap structure is an important point of consideration for the immunogenicity of your mRNA-based product. Whereas legacy cap analogs produce a Cap0 structure and are recognized by the immune ...