Advil PM and Tylenol PM contain drugs that may have side effects. Diphenhydramine in both medications Both products contain diphenhydramine, which commonly causes sleepiness as a common side effect.

Tylenol vs. Advil vs. Aleve Advil (ibuprofen) and Aleve (naproxen) are non-steroidal anti-inflammatory drugs . They work by inhibiting an enzyme in the body called cyclooxygenase, or COX for short.

People often use the wrong painkiller or take too much too quickly, increasing the risk of side effects, say pharmacists. Here are safer and more effective ways to take drugs like Advil and Tylenol.