Tylenol vs. Advil vs. Aleve Advil (ibuprofen) and Aleve (naproxen) are non-steroidal anti-inflammatory drugs . They work by inhibiting an enzyme in the body called cyclooxygenase, or COX for short.

People often use the wrong painkiller or take too much too quickly, increasing the risk of side effects, say pharmacists. Here are safer and more effective ways to take drugs like Advil and Tylenol.

Acetaminophen (Tylenol) is most effective for more mild pain that is not caused by inflammation, Dr. Peperzak said. It can help with mild arthritis pain or tension headaches, for example, Dr ...