Wnt-1 and Wnt-3a exhibit redundancy in neural crest development. We have found that they do not produce the same effects on PC12 cells, which were obtained from the adrenal medulla, a neural crest ...

Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways have been ...

Previous studies have demonstrated that noncanonical Wnt family members repress canonical Wnt signaling by inducing a calcium influx. [5,7,20–22] Some regulators of calcium signaling also have ...

Wnt signaling controls both development and homeostasis, and its disruption is implicated in a wide range of human diseases. 6-10 The human genome encodes 19 Wnt ligands, which have unique and yet ...

A Wnt/β-catenin pathway agonist under development by Surrozen appears to be effective against idiopathic pulmonary fibrosis (IPF) in mouse models, according to new data.. The results, published ...

Researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation. The findings shed light on the ...

Company prioritizes ophthalmology pipeline programs with potential to provide new or improved treatment options in multiple severe and disabling eye diseases Announces an oversubscribed financing ...

A new study reveals why some pancreatic and colorectal tumors resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to patients with fully treatment-resistant cancers.

Wnt proteins contain palmitoleic acid, an unusual lipid modification. Production of an active Wnt signal requires the acyltransferase Porcupine (Porcn) and depends on the attachment of palmitoleic ...

Aberrant Wnt signaling has also been identified as a key mechanism in cancer biology. This article summarizes both the canonical (β-catenin dependent) and non-canonical (β-catenin independent) ...