The Rams will also be without key players as star wideouts Cooper Kupp and Puka Nacua are both out; Nacua is on injured reserve with a knee injury stemming from Week 1 while Kupp was ruled out with an ankle injury suffered last week. Los Angeles already has five offensive linemen on IR.

The Rams are too injured and while the 49ers are just injured. Their lines are both healthy which will be critical for running the ball and getting to Matthew Staffo

The 49ers’ offense provided one of the toughest challenges for defense due to their ability to line up two of the most unique players at their respective positions. Christian McCaffrey is a running back who runs routes and catches passes like a wide receiver.