Hunter Greene was scheduled to throw a maximum of 80 pitches in what was his return appearance from the 15-day injured list, but he was still on pace to get through five innings until Chicago's Nico Hoerner worked a 12-pitch at-bat in the fourth inning.

The Cincinnati Reds ' starting pitching depth took a hit via Rhett Lowder's latest injury. After exiting his Thursday start for Triple-A Louisville in the second inning after 12 pitches, Lowder on Friday was said by Reds manager Terry Francona to have a "fairly significant" left oblique strain.

Lowder was diagnosed with a left oblique strain after he exited his rehab start for Triple-A Louisville on Thursday.

Pete Crow-Armstrong hit two home runs, including a grand slam to highlight a six-run seventh inning, and Seiya Suzuki went 3-for-5 with a home run, double and three RBIs as the visiting Chicago Cubs rallied from a 4-0 deficit to defeat the Cincinnati Reds,

Like the rest of the Cincinnati Reds, Hunter Greene’s night looked like it was going great until suddenly it wasn’t on Friday against the Chicago Cubs. And, well, Cubs center fielder Pete Crow-Armstrong played a large role in Greene’s short night and the Reds’ 13-6 series-opening loss.