Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.

Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.

The chirality of tissues and organs is essential for their proper function and development. Tissue-level chirality derives from the chirality of individual cells that comprise the tissue, and cellular ...

This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

Here, we address this question further by combining large-scale electrophysiological recordings, to characterize the functional connectivity of developing neuronal networks in vitro, with a generative ...

A compound found in fungal cell walls can reprogram immune cells in the lungs, potentially worsening inflammation during infections.

Rats exhibit significant recovery of locomotor function following incomplete spinal cord injuries, albeit with altered gait expression and reduced speed and stepping frequency. These changes likely ...

This important work offers a fresh perspective central to merozoite surface biology and potential implications on vaccine design, challenging the dogma that MSPs are indispensable invasion engines.

Reviewer #3 (Public review): Summary: This important study shows that stationary phase bacteria survive antimicrobial peptide treatment by switching on efflux pumps, generating low accumulating ...

eLife Assessment This study makes an important contribution by showing that humans adapt learning rates rationally to environmental volatility yet systematically misattribute noise as volatility, ...

Ascidians (also known as sea squirts) are small marine animals. Ascidian larvae have tadpole-like bodies and swim by beating their tail, but the adults have a vase-like shape, no tail and are attached ...

Exosomal mRNA transfer from non-neuronal cells to neurons under hypoxia drives hemoglobin expression and preserves mitochondrial homeostasis as an intercellular protective mechanism.