Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024).Androgen receptor (AR) is considered ...

Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

This cover highlights the article Early coordination of cell migration and cardiac fate determination during mammalian gastrulation by Shayma Abukar, Kenzo Ivanovitch and colleagues. Using long-term ...

Evolution has only explored an infinitesimal portion of the potential protein sequence landscape (Huang et al, 2016).Enormous potential, therefore, exists in unlocking the principles of protein ...

Chloride (Cl −) ions cause major damage to crops in saline soils.Understanding the key factors that influence Cl − uptake and translocation will aid the breeding of more salt-tolerant crops. Here, ...

Arabidopsis genome encodes approximately 60 putative MAPKKKs, 10 MAPKKs, and 20 MAPKs (MAPK‐Group, 2002).MAPK cascades have been shown to regulate diverse aspects of plant biology, including plant ...

How myristic acid contributes to these changes is underexplored. Protein lipidation mediates membrane localisation, proteolytic degradation and can stabilise protein complexes (Jiang et al, 2018).In ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Fungal infections and autoimmunity share a ...

Quiescent cells have been described in different tumor types as a relatively small-sized subpopulation within the tumor characterized by a temporary and reversible cell cycle arrest (Nabil et al, 2021 ...

This month's cover highlights the article EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer by Dana Krauß, Maria Sibilia and colleagues. The tumor-intrinsic role of ...