Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer ...

miPEP31, encoded by the primary transcript of miR‐31, is a cell‐penetrating peptide which promotes Treg differentiation. Synthesized miPEP31 enhances the induction of peripheral Tregs and suppresses ...

Intriguingly, single-cell transcriptome profiling of fetal gonads from both humans and mice shows that MCM8 is also highly expressed in PGCs undergoing rapid mitosis (Li et al, 2017; Niu and Spradling ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

We recently discovered that the binding of mitochondrial precursor proteins to the ER surface is not simply the result of an unavoidable mislocalization, but rather that the ER-to-mitochondria ...

Motile cells can use and switch between different modes of migration. Here, we use traction force microscopy and fluorescent labeling of actin and myosin to quantify and correlate traction force ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

In this study, we generated new in-vivo treatment models of Brca1- and Bard1-mutant breast cancer that recapitulate the striking response to PARPi, acquired resistance, and recurrence that is observed ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...

To overcome this challenge, cells use sterol products of the mevalonate pathway to negatively regulate its activity at two critical nodes. The first of these nodes is the sterol regulatory ...