We found that the amino acid glutamine is required to activate the mevalonate pathway. Glutamine starvation inhibited cholesterol synthesis and blocked transcription of the mevalonate pathway—even in ...

There are two types of glutamine: L-glutamine and D-glutamine. While they are very similar, they have slightly different molecular structures. Many foods contain abundant amounts of L-glutamine ...

Actemra was a major contributor to this outperformance, as the company observed slower-than-anticipated erosion from biosimilars. “3Q sales are a small positive, but we largely see the ...

Actemra (tocilizumab) is a monoclonal antibody that inhibits the interleukin-6 (IL-6) receptor. Two major concerns with these drugs include the risk of serious infection or lymphoma. Krystexxa ...

The growing portfolio of inflammatory and immune diseases and oncology biosimilars is a testament to the company's commitment to biosimilars Fresenius Kabi (CNW Group/Fresenius Kabi Canada Inc ...

Triple-negative breast cancer (TNBC) metabolism and cell growth uniquely rely on glutamine uptake by the transporter ASCT2. Despite previous data reporting cell growth inhibition after ASCT2 knockdown ...

Explore the expanding Actemra market, fueled by rising autoimmune disease prevalence and increasing adoption in treatment protocols worldwide. The Actemra drug market is estimated to be valued at ...

Roche’s Actemra may help fight pandemic after all with phase 3 trial results showing it cut the chances of COVID-19 patients, mainly from higher risk minority ethnic backgrounds with pneumonia ...

Roche's arthritis drug Actemra has become a key treatment for people with severe COVID-19, leading to shortages, and the World Health Organisation (WHO) wants the company to ensure that supplies ...

Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine ...