Antimicrobial-resistant infections have long been a looming public health threat, and the situation was exacerbated during the COVID-19 pandemic with increased antibiotic use and fewer prevention ...

Lariocidin hits drug-resistant bacteria where others fail — by hijacking the ribosome at a new site, bypassing defences, and opening the door to a new generation of antibiotics. Lariocidin, a ...

T. thermophilus HB27 strain expressing Cfr-like methylase. Credit: Nature Chemical Biology (2024). DOI: 10.1038/s41589-023-01525-w Scientists at the University of Illinois Chicago and Harvard ...

Antibiotics that inhibit protein synthesis are known to have some degree of antivirulence effects. Macrolides bind reversibly to 23S ribosomal RNA (rRNA) of the 50S subunit of bacterial ribosome ...

This image highlights two alternatives for the ribosome to be recruited to an mRNA that is still being synthesized by RNA polymerase (RNAP). RNAP (left, red) can directly deliver the mRNA to the entry ...

The world urgently needs new antibiotics. In 2019 alone, antibiotic-resistant bacteria killed more than 4.5 million people worldwide. The bacteria that cause these infections evolve constantly, ...

An international team of scientists have used advanced microscopy to image how ribosomes recruit to mRNA. Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell ...

In a recent article published in the journal Science, researchers unveiled an exciting breakthrough in the ongoing battle against antibiotic resistance. This breakthrough involves the development of a ...

SAN DIEGO — In the ongoing battle against antibiotic-resistant “superbugs,” researchers have uncovered an unexpected ...