By tethering RNA polymerase with the coupling transcription factor NusG or its paralog or version, RfaH, which threads the ...

Several classes of antibiotics target the bacterial ribosome to block protein synthesis. However, ribosome modifications that disrupt antibiotic binding lead to resistance. Reporting in Cell ...

Now scientists have captured the first images of one important class of these enzymes in action. The images show how the enzymes latch onto a particular site on the bacterial ribosome and squeeze ...

Scientists at St. Jude Children’s Research Hospital report that human ribosomes decode messenger RNA (mRNA) 10 times slower than bacterial ribosomes, but do so more accurately. The study “mRNA ...

Many antibiotics interfere with the function of the bacterial ribosome by preventing or retarding this translocational movement. Understanding the structural and dynamic details of this movement could ...

Humans vs. Bacteria: Differences in ribosome decoding revealed Date: April 5, 2023 Source: St. Jude Children's Research Hospital Summary: Scientists have found that human ribosomes decode mRNA ...

The ribosome is vital because it translates genetic instructions into proteins needed for bacterial growth. By interrupting this critical process, lariocidin effectively halts bacterial survival.

Humans vs. Bacteria: Differences in ribosome decoding revealed. St. Jude Children's Research Hospital. Journal Nature DOI 10.1038/s41586-023-05908-w ...

The ribosome is the cell structure that produces proteins. Moreover, the macrolones were able to block ribosomes inside bacterial strains that are already resistant to macrolids.

Advanced microscopy techniques give scientists valuable clues for how to fight an enzyme that is leading to a rise in cases of antibiotic-resistant bacterial infections worldwide.