Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

second that the essential roles of TRAF6 in initiating innate immune signalling are independent of its E3 ligase activity; third that the HOIL-1 component of the Linear Ubiquitin Assembly Complex ...

If we had a penny for all the Halo E3 demos to be made publicly available, we’d have two pennies (Microsoft) Last November, Microsoft and 343 Industries (or Halo Studios as it’s now called ...

FILE - A boy rides his bicycle past apartment buildings as a rally staged by the East Colfax Community Collective is held in the courtyard to address chronic problems in the apartment buildings ...

Importantly, AUCell analysis revealed that CHIP E3 ubiquitin ligase activity deficiency affected ubiquitin-mediated proteolysis, ultimately increasing the level of intracellular cAMP. The activation ...

Fluorescence intensity measurements were used to monitor the cleavage of a ubiquitin-rhodamine substrate. All activity assays were performed in black 384-well plates in assay buffer (20 mM Tris–HCl, ...

A Yale study finds that the Earth’s ozone layer, crucial for life’s protection from UV radiation, was delayed in stabilizing by a battle between iodine and oxygen, hindering the emergence of complex ...

The platform studies E3 ubiquitin ligases, enzymes that allow the selective ... has so far presented promising results in patients with complex B-cell malignancies. According to Seeking Alpha ...

Under normal growth conditions, N-myc downstream regulated gene 3 (NDRG3) undergoes hydroxylation by PHD2 and ubiquitinated for degradation by VHL, a targeted element of the E3 ubiquitin ligase ...