With a pair of new methods, they are expanding the capabilities of expansion microscopy—a high-resolution imaging technique ...

In ExIGS, expansion microscopy is integrated with in situ genome sequencing to simultaneously sequence genomic DNA and image nuclear proteins at nanoscale resolution within single cells.

Now a decade old, the expansion process is being applied to other methods outside traditional microscopy. Wang, Tillberg, and their collaborators at Janelia and the University of Wisconsin-Madison ...

Instead of relying on lenses to zoom in, expansion microscopy physically enlarges biological tissues by embedding them in a hydrogel, a water-absorbing polymer that can expand without losing its ...

Jan 04, 2023: New expansion microscopy methods magnify research's impact (Nanowerk News) Unprecedented views of the interior of cells and other nanoscale structures are now possible thanks to ...

Unprecedented views of the interior of cells and other nanoscale structures are now possible thanks to innovations in expansion microscopy. The advancements could help provide future insight into ...

Visualizing nanoscale events like cell-ECM binding is hindered by the diffraction limits imposed by conventional microscopy, which has led us to develop a novel photochemistry for facile expansion ...

Expansion microscopy (ExM) is a route to bioimaging in which a crosslinked swellable hydrogel is used to physically expand fluorescently labelled tissues without disturbing the cellular structure.

Expansion microscopy is a way of achieving the equivalent of superresolution with an ordinary diffraction-limited optical microscope. Fluorescently labeled tissue samples are embedded in a gel, ...

Boyden's lab invented expansion microscopy in 2015. The technique requires embedding tissue into an absorbent polymer and breaking apart the proteins that normally hold tissue together.

Expansion microscopy (ExM) is a route to bioimaging in which a crosslinked swellable hydrogel is used to physically expand fluorescently labelled tissues without disturbing the cellular structure.