This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

Munsterberg, A. E. & Weijer, C. J. Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev. Cell 3, 425–437 (2002).

Why examine PS-LC induction only in FGF17 heterozygous cells and not homozygous FGF17 nulls? (4) The idea that FGF8 plays a dominant role during gastrulation of other species but not humans is so ...